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Title: High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial
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IDEAL Trial Overview 1. ♦ a multi-center prospective randomized open-label, blinded end-point trial to determine lipid lowering effects of high dose atorvastatin
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RESULTS: In the IDEAL trial, compared with patients taking simvastatin 20 to 40 mg daily, patients receiving atorvastatin 80 mg daily had their relative risk of a
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of myocardial infarction (MI)—in the IDEAL study.2,3. • In a subgroup of TNT participants with diabetes, treatment with atorvastatin. 80 mg led to a significant
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To the Editor: The IDEAL study1 reported that high-dose atorvastatin (80 mg/d) was more beneficial in preventing recurrent nonfatal myocardial
A similar result was observed in the IDEAL trial, in which the effects of low-dose simvastatin were compared with the effects of high-dose atorvastatin.7 The
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The Incremental Decrease in Events through. Aggressive Lipid Lowering (IDEAL) study is comparing atorvastatin 80 mg versus simvastatin 20 or 40 mg [35].
In the TNT trial (N=10001) in patients with CHD, LIPITOR 80 mg* provided a 22% . **Trials include ASCOT-LLA,13 CARDS,9 IDEAL,19 PROVE IT (a study
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Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease ( CHD) In Patients With Known CHD (IDEAL). This study has
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Data Sources: Studies found in the PubMed, MEDLINE,. EMBASE . form.32 The IDEAL (Incremental De- crease in atorvastatin, 80 mg (3 studies)19,20,28;
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High-dose atorvastatin vs. usual-dose simvastatin for secondary prevention after myocardial infarction. The IDEAL study: A randomized controlled trial.
dose atorvastatin group (6, 0.1%). Incremental Decrease in Endpoints through Aggressive Lipid Lowering. Study (IDEAL). In IDEAL [see Clinical Studies (14.1)]
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A.dh Atorvastatin Clinical Study Program Introduction - Atorvastatin Clinical Endpoint Studies : ALLIANCE, ASCOT,ASPEN,AVERT, CARDS, 4D,IDEAL,
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IDEAL Study: Effect of Treatment on LDL-C LDL-lowering therapy with atorvastatin 80 mg/d could provide incremental cardiovascular benefits beyond the risk
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Background and objectives: Data suggest that atorvastatin may be nephroprotective. This subanalysis of the Treating to New Targets study investigated .. myocardial infarction: The IDEAL study—A randomized controlled
In the IDEAL (Incremental Decrease in Endpoints through Aggressive Lipid Lowering) trial, 239 of 3737 patients randomized to atorvastatin 80
(IDEAL) trial, randomized 8888 patients with a history of acute MI (AMI) to either 80 mg/day atorvastatin (the high dose treatment) or 20 mg/day simvastatin (the
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atorvastatin 10 mg. 8600Patients atorvastatin 80 mg LDLlt 130 mg 750 events or 5 years 8 weeks 39. IDEAL Study Design Incremental Decrease in. Endpoints
The Incremental Decrease in End Points Through Aggressive Lipid Lowering ( IDEAL) study compared atorvastatin 80mg daily with simvastatin 20mg daily
The safety of atorvastatin (80 mg) and simvastatin (20 to 40 mg) was similar in Thus, in some respects, the IDEAL study design resembled everyday clinical
In this post-hoc analysis of the IDEAL study we demonstrated that CHD patients prescribed atorvastatin (80 mg per day) reach the 2.5 mmol/l
IDEAL study r atorvastatin 80mg (%LDL r55%) compared with simvastatin 20mg ( %LDL r35%) failed to reach the primary prerspecified endpoint with no
The ideal NNT is 1, where everyone improves with treatment and no one manufacturer-sponsored study addressed the benefit of atorvastatin 10 mg (a
The current generation of statin studies is evaluating whether intensive statin Aggressive Lipid Lowering (IDEAL), and Treating to New Targets (TNT) have did show that atorvastatin was able to prevent progression of atherosclerosis as
0.226). In the IDEAL (Incremental Decrease in End Points. Through Aggressive Lipid Lowering) trial, 239 of 3737 patients randomized to atorvastatin 80 mg/day
Studies with atorvastatin: After oral administration alone, atorvastatin is rapidly .. (IDEAL), treatment with LIPITOR 80 mg/day was compared to treatment with
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However, the information and studies comparing simvastatin vs atorvastatin are in End Points Through Aggressive Lipid Lowering (IDEAL) Study Group).
High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention After. Myocardial Infarction The IDEAL Study: A Randomized Controlled Trial.
for inclusion, studies had to compare placebo or usual care simvastatin (2 trials ), or atorvastatin (3 trials) for Some recent trials such as IDEAL and TNT have
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The study confirms further mg in elderly person patients NEW YORK to the amp ; quot; The new IDEAL economic analysis of the health lipitor
seen in the AFCAPS/TexCAPS trial which demonstrated that the best overall . hypertensive patients (14) and the Collaborative Atorvastatin Diabetes Study
In a modelled analysis based on results of the IDEAL trial, which showed significant reductions in cardiovascular endpoints with high-dose atorvastatin (80
values in support of using top-dose atorvastatin (80 mg/day) versus The background: The IDEAL study was an apparently well-run,
the Incremental Decrease in End Points Through Aggressive Lipid Lowering ( IDEAL) study compared the effectiveness of high-dose atorvastatin (80mg daily)
Our present study examined the hypothesis that atorvastatin increased oxidative .. in End Points Through Aggressive Lipid Lowering (IDEAL) Study Group.
"In this study, high-dose atorvastatin failed to achieve that optional goal. The IDEAL researchers concluded that the evidence suggested that
dose statins (atorvastatin 80 mg) versus usual sta- cent studies, such as the ones reported in Treating events) the IDEAL trial showed a significant 13%
High-dose Atorvastatin vs Usual-dose Simvastatin for Secondary Prevention After Myocardial Infarction The IDEAL study: A Randomized Controlled Trial By:
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To the Editor: In the IDEAL study, Dr Pedersen and colleagues 1 did not of simvastatin or 80 mg/d of atorvastatin experienced adverse effects,
resins or nonformulary ezetimibe) or a nonformulary switch to atorvastatin .. determine if “lower is better” is called the IDEAL study. IDEAL is comparing the
In a post hoc analysis of the IDEAL study atorvastatin 80mg was compared with simvastatin 20-40mg over 5 years in patients with a history of MI. In patients
The investigators of the IDEAL study, therefore, reasoned that an additional decrease in LDL cholesterol of 0.6 to 0.7 mmol/L, using 80 mg of atorvastatin ( which
An economic evaluation based on data collected during the IDEAL trial indicated that intensive lipid lowering with atorvastatin 80 mg would be cost-effective
To clarify these findings, the IDEAL study was designed to determine whether atorvastatin 80 mg would safely reduce the rate of major adverse coronary events
ABSTRACT. The clinical failure of Vytorin in the ENHANCE trial supports the atorvastatin (Lipitor), the last being the world's best-selling drug. Vytorin is a
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