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Osman, O.T., Hsiao, J.K., Risby, E.D., Potter, W.Z.: Dose-dependent effects of intravenous alprazolam on neuroendocrine, biochemical, cardiovascular and
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Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers. J Clin Pharmacol. 2005 May;45(5):529-37.
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Intravenous alprazolam dosing was chosen to facilitate selecting the appropriate The animals initially received an i.v. dose of alprazolam (1.2
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1 Healthy volunteers received single doses of three benzodiazepines (diazepam, 10 mg. i.v.; alprazolam, 1.0 mg orally; lorazepam, 2 mg i.v.) on two occasions
Pharmacokinetic and dynamic correlates of intravenous alprazolam challenge. Osman OT, DeVane CL, Greenblatt DJ, Potter WZ. Section on Clinical
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Other experiments in animals have indicated that cardiopulmonary collapse can occur following massive intravenous doses of alprazolam
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